Duke vs Niagara College Basketball Prediction, Odds, Picks, Best Bets for Nov. 21

The Duke Blue Devils (5-0) hope to continue a four-game home win streak when they host the Niagara Purple Eagles (2-2) on November 21, 2025.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Duke vs. Niagara Game Info and Odds

• Game day: Friday, November 21, 2025
• Game time: 7 p.m. ET
• TV channel: ACC Network
• Location: Durham, North Carolina
• Arena: Cameron Indoor Stadium

Before making a wager on Friday's Duke-Niagara spread (Duke -39.5) or total (146.5 points), read the betting insights and trends below.

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Duke vs. Niagara: ATS Betting Stats and Trends

• Duke covered 25 times in 39 matchups with a spread last season.
• Niagara went 13-17-0 ATS last season.
• The Blue Devils covered the spread in a lower percentage of their home games than away games last season. They covered 11 times in 17 games at home, and they covered nine times in 11 games when playing on the road.
• Last year, the Purple Eagles were 4-8-0 at home against the spread (.333 winning percentage). On the road, they were 7-9-0 ATS (.438).

Duke vs. Niagara Head-to-Head Comparison

• Duke was the 11th-best squad in the nation in points scored (83.2 per game) and seventh-best in points conceded (62.8) last year.
• Duke was the 24th-best squad in the country in rebounds per game (35.6) and 12th-best in rebounds conceded (27.3) last year.
• Duke was 17th-best in the country in assists (16.9 per game) last season.
• In terms of turnovers, Duke was ninth-best in the nation in committing them (8.9 per game) last season. It was 265th in forcing them (10.4 per game).
• With 68.5 points per game on offense, Niagara ranked 313th in college basketball last season. Defensively, it surrendered 71.4 points per contest, which ranked 156th in college basketball.
• Niagara struggled to rack up rebounds last season, ranking 15th-worst in college basketball with 27.9 boards per game. It ranked 104th by allowing 30.1 rebounds per contest.
• Niagara ranked 260th in college basketball with 12.5 assists per game.
• Niagara was 221st in the nation with 11.5 turnovers per game last season. Meanwhile, it ranked 234th with 10.7 forced turnovers per contest.

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