Duke vs Louisville College Basketball Prediction, Odds, Picks, Best Bets for Jan. 26

The Duke Blue Devils (18-1, 7-0 ACC) will look to continue a seven-game winning streak when they host the Louisville Cardinals (14-5, 4-3 ACC) on January 26, 2026 at Cameron Indoor Stadium.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Duke vs. Louisville Game Info and Odds

• Game day: Monday, January 26, 2026
• Game time: 7 p.m. ET
• TV channel: ESPN
• Location: Durham, North Carolina
• Arena: Cameron Indoor Stadium

Duke vs. Louisville Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Duke win (71.7%)

Read these betting insights and trends before you bet on Monday's Duke-Louisville spread (Duke -7.5) or over/under (157.5 points).

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Duke vs. Louisville: ATS Betting Stats and Trends

• Duke has put together a 10-9-0 ATS record so far this year.
• Louisville has put together an 11-8-0 ATS record so far this season.
• In home games, the Blue Devils own a worse record against the spread (3-6-0) compared to their ATS record in away games (5-1-0).
• The Cardinals' winning percentage against the spread at home is .583 (7-5-0). On the road, it is .400 (2-3-0).
• Against the spread, in conference games, Duke is 4-3-0 this season.
• Louisville has covered the spread three times in seven ACC games.

Duke vs. Louisville: Moneyline Betting Stats

• Duke has been the moneyline favorite in 13 games this season and has come away with the win 12 times (92.3%) in those contests.
• The Blue Devils have a win-loss record of 10-1 when favored by -350 or better by oddsmakers this year.
• Louisville has been the moneyline underdog only two other times so far this season, and it lost both games.
• The Cardinals have not yet played a game with moneyline odds of +270 or longer.
• Duke has an implied victory probability of 77.8% according to the moneyline set for this matchup.

Duke vs. Louisville Head-to-Head Comparison

• Last season, Duke was 11th-best in the country offensively (83.2 points scored per game) and seventh-best on defense (62.8 points allowed).
• On the boards, Duke was 24th-best in the nation in rebounds (35.6 per game) last season. It was 12th-best in rebounds conceded (27.3 per game).
• Last season Duke was 17th-best in the country in assists with 16.9 per game.
• Duke was the ninth-best squad in the country in turnovers per game (8.9) and 265th in turnovers forced (10.4) last year.
• Louisville was 65th in the nation last year with 78.5 points per game. At the other end of the court, it ranked 89th with 69.5 points allowed per game.
• With 34.6 rebounds per game, Louisville ranked 47th in the nation. It allowed 30.2 rebounds per contest, which ranked 114th in college basketball.
• Louisville dished out 13.9 dimes per game, which ranked them 148th in college basketball.
• With 10.9 turnovers per game, Louisville was 150th in college basketball. It forced 12.2 turnovers per contest, which ranked 93rd in college basketball.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!