Cubs vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for July 26

Odds updated as of 7:11 p.m.

Saturday's slate in the MLB includes a matchup between the Chicago Cubs and the Chicago White Sox.

All the info you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cubs vs White Sox Game Info

• Chicago Cubs (60-43) vs. Chicago White Sox (38-66)
• Date: Saturday, July 26, 2025
• Time: 7:10 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and MARQ

Cubs vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-188) | CHW: (+158)
• Spread: CHC: -1.5 (-118) | CHW: +1.5 (-102)
• Total: 9 -- Over: (-110) | Under: (-110)

Cubs vs White Sox Probable Starting Pitchers

Probable Pitchers: Cade Horton (Cubs) - 3-3, 4.04 ERA vs Aaron Civale (White Sox) - 2-6, 4.76 ERA

The probable starters are Cade Horton (3-3) for the Cubs and Aaron Civale (2-6) for the White Sox. When Horton starts, his team is 4-7-0 against the spread this season. Horton's team has been victorious in 85.7% of the games he's started as the moneyline favorite with a record of 6-1. The White Sox have a 5-7-0 ATS record in Civale's 12 starts that had a set spread. The White Sox have been the moneyline underdog in 10 of Civale's starts this season, and they went 2-8 in those matchups.

Cubs vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (57.4%)

Cubs vs White Sox Moneyline

• The Cubs vs White Sox moneyline has the Cubs as a -188 favorite, while the White Sox are a +158 underdog at home.

Cubs vs White Sox Spread

• The Cubs are 1.5-run favorites on the runline against the White Sox. The Cubs are -118 to cover, while the White Sox are -102 to cover.

Cubs vs White Sox Over/Under

• The Cubs-White Sox contest on July 26 has been given an over/under of 9 runs. The over is set at -110 and the under at -110.

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Cubs vs White Sox Betting Trends

• The Cubs have won in 45, or 68.2%, of the 66 contests they have been named as odds-on favorites in this year.
• This year, the Cubs have won 12 of 13 games when listed as at least -188 or better on the moneyline.
• The Cubs and their opponents have hit the over in 51 of their 100 games with a total this season.
• The Cubs have posted a record of 49-51-0 against the spread this season.
• The White Sox have put together a 35-62 record in games they were listed as the moneyline underdog (winning 36.1% of those games).
• In games they have played as a moneyline underdog with odds of +158 or longer, the White Sox have gone 11-32 (25.6%).
• The White Sox have played in 100 games with a set over/under, and have combined with their opponents to go over the total 45 times (45-50-5).
• The White Sox have a 56-44-0 record against the spread this season (covering 56% of the time).

Cubs Player Leaders

• Kyle Tucker leads Chicago with an OBP of .383 this season while batting .275 with 66 walks and 71 runs scored. He has a slugging percentage of .491.
• Among qualifying batters in MLB, his batting average ranks 47th, his on-base percentage ranks seventh, and he is 26th in slugging.
• Pete Crow-Armstrong leads Chicago in total hits (106) this season while batting .268 with 56 extra-base hits. He's slugging .556 with an on-base percentage of .304.
• He is 64th in batting average, 127th in on-base percentage and eighth in slugging among qualifying batters.
• Seiya Suzuki is batting .254 with a .529 slugging percentage and 81 RBI this year.
• Nico Hoerner has an OPS of .705, fueled by an OBP of .332 and a team-best slugging percentage of .373 this season.
• Hoerner heads into this matchup on a three-game hitting streak. In his last five games he is hitting .286 with an RBI.

White Sox Player Leaders

• Miguel Vargas has accumulated a slugging percentage of .406, a team-high for the White Sox. He's batting .229 with an on-base percentage of .310.
• Including all qualified hitters in MLB, he is 138th in batting average, 117th in on-base percentage and 99th in slugging percentage.
• Andrew Benintendi has 12 doubles, two triples, 11 home runs and 27 walks while hitting .235. He's slugging .420 with an on-base percentage of .305.
• Chase Meidroth a has .334 on-base percentage to pace the White Sox.
• Luis Robert is batting .206 with nine doubles, 10 home runs and 35 walks.

Cubs vs White Sox Head to Head

• 7/25/2025: 12-5 CHW (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -186, Underdog Moneyline: +156)
• 5/18/2025: 6-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -260, Underdog Moneyline: +215)
• 5/17/2025: 7-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 10, Favorite Moneyline: -310, Underdog Moneyline: +250)
• 5/16/2025: 13-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 11.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 8/10/2024: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 8/9/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 6/5/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 6/4/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -300, Underdog Moneyline: +245)
• 8/16/2023: 4-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 11, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 8/15/2023: 5-3 CHW (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)

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