Cubs vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for NL Wild Card Game 1 on Sept. 30

Odds updated as of 2:12 p.m.

The Chicago Cubs will take on the San Diego Padres for Game 1 of the NL Wild Card Series on Tuesday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this game.

Cubs vs Padres Game Info

• Chicago Cubs (92-70) vs. San Diego Padres (90-72)
• Date: Tuesday, September 30, 2025
• Time: 3:08 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: ABC

Cubs vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-126) | SD: (+108)
• Spread: CHC: -1.5 (+184) | SD: +1.5 (-225)
• Total: 6.5 -- Over: (-124) | Under: (+102)

Cubs vs Padres Probable Starting Pitchers

Probable Pitchers: Matthew Boyd (Cubs) - 14-8, 3.21 ERA vs Nick Pivetta (Padres) - 13-5, 2.87 ERA

The Cubs will look to Matthew Boyd (14-8, 3.21 ERA) versus the Padres and Nick Pivetta (13-5, 2.87 ERA). Boyd's team is 13-17-0 against the spread in his starts this season. Boyd's team is 14-10 this season when he starts and they are the moneyline favorite. The Padres have an 18-13-0 ATS record in Pivetta's 31 starts that had a set spread. The Padres are 7-3 in Pivetta's 10 starts this season that they were the moneyline underdog.

Cubs vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (54.3%)

Cubs vs Padres Moneyline

• Looking at the moneyline for Padres-Cubs, San Diego is the underdog at +108, and Chicago is -126 playing at home.

Cubs vs Padres Spread

• The Padres are at the Cubs, and are +1.5 on the runline. The Padres are +184 to cover the spread, and the Cubs are -225.

Cubs vs Padres Over/Under

• A combined run total of 6.5 has been set for Cubs-Padres on Sept. 30, with the over at -124 and the under at +102.

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Cubs vs Padres Betting Trends

• The Cubs have come away with 70 wins in the 108 contests they have been listed as the favorites in this season.
• Chicago has a record of 59-28 in contests when bookmakers favor them by -126 or more on the moneyline.
• Contests with the Cubs have gone over the total set by bookmakers in 74 of 157 chances this season.
• The Cubs have posted a record of 75-82-0 against the spread this season.
• The Padres have been the moneyline underdog 67 total times this season. They've finished 33-34 in those games.
• In games it has played as a moneyline underdog with odds of +108 or longer, San Diego has gone 22-25 (46.8%).
• The Padres have played in 160 games with a set over/under, and have combined with their opponents to go over the total 70 times (70-87-3).
• The Padres have put together an 87-73-0 record against the spread this season (covering 54.4% of the time).

Cubs Player Leaders

• Kyle Tucker leads Chicago with an OBP of .377 this season while batting .266 with 87 walks and 91 runs scored. He has a slugging percentage of .464.
• Among all qualifying hitters in baseball, he ranks 46th in batting average, seventh in on-base percentage, and 44th in slugging.
• Nico Hoerner has an OPS of .739, fueled by an OBP of .345 and a team-best slugging percentage of .394 this season. He's batting .297.
• Among qualified hitters, he ranks eighth in batting average, 46th in on-base percentage and 110th in slugging percentage.
• Pete Crow-Armstrong has collected 146 base hits, an OBP of .287 and a slugging percentage of .481 this season.
• Crow-Armstrong enters this game with four games in a row with at least one hit. In his last five games he is hitting .294 with two home runs and five RBIs.
• Seiya Suzuki has 32 home runs, 103 RBI and a batting average of .245 this season.
• Suzuki takes a seven-game hitting streak into this game. During his last 10 games he is hitting .281 with two doubles, five home runs, four walks and 12 RBIs.

Padres Player Leaders

• Fernando Tatis Jr. has racked up a team-high .368 on-base percentage. He's batting .268 and slugging .446.
• Including all the qualified hitters in MLB, he is 43rd in batting average, 10th in on-base percentage and 60th in slugging percentage.
• Tatis takes an eight-game hitting streak into this matchup. During his last 10 outings he is hitting .368 with three home runs, four walks and six RBIs.
• Manny Machado has collected 169 hits to pace his team. He has a batting average of .275 while slugging .460 with an on-base percentage of .335.
• Including all qualified hitters, his batting average puts him 33rd, his on-base percentage is 58th, and he is 49th in slugging.
• Luis Arraez has accumulated a team-high .392 slugging percentage.
• Ryan O'Hearn is hitting .281 with 21 doubles, a triple, 17 home runs and 58 walks.

Cubs vs Padres Head to Head

• 4/16/2025: 4-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/15/2025: 2-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 4/14/2025: 10-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 4/6/2025: 8-7 SD (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/5/2025: 7-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/4/2025: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/8/2024: 3-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 5/7/2024: 3-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 5/6/2024: 6-3 SD (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/10/2024: 10-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -152, Underdog Moneyline: +128)

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