Cubs vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 27

Odds updated as of 10:12 a.m.

The MLB's Wednesday schedule includes the Chicago Cubs taking on the San Francisco Giants.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding this game.

Cubs vs Giants Game Info

• Chicago Cubs (76-56) vs. San Francisco Giants (64-68)
• Date: Wednesday, August 27, 2025
• Time: 9:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and MARQ

Cubs vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-126) | SF: (+108)
• Spread: CHC: -1.5 (+136) | SF: +1.5 (-164)
• Total: 8.5 -- Over: (-108) | Under: (-112)

Cubs vs Giants Probable Starting Pitchers

Probable Pitchers: Colin Rea (Cubs) - 10-5, 3.96 ERA vs Carson Whisenhunt (Giants) - 1-1, 4.91 ERA

The Cubs will give the nod to Colin Rea (10-5) against the Giants and Carson Whisenhunt (1-1). Rea's team is 13-8-0 against the spread this season in his starts. Rea's team has won 61.5% of his starts when they are favored on the moneyline (8-5). When Whisenhunt starts, the Giants have gone 2-2-0 against the spread. The Giants were the moneyline underdog for two Whisenhunt starts this season -- they split the games.

Cubs vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (58.9%)

Cubs vs Giants Moneyline

• San Francisco is the underdog, +108 on the moneyline, while Chicago is a -126 favorite despite being on the road.

Cubs vs Giants Spread

• The Giants are +1.5 on the spread (-164 to cover), and Chicago is +136 to cover the runline.

Cubs vs Giants Over/Under

• The Cubs-Giants game on Aug. 27 has been given an over/under of 8.5 runs. The over is set at -108 and the under at -112.

Bet on Chicago Cubs vs. San Francisco Giants on FanDuel today!

Cubs vs Giants Betting Trends

• The Cubs have been victorious in 57, or 64.8%, of the 88 contests they have been chosen as favorites in this season.
• Chicago has a record of 49-23 in contests when bookmakers favor them by -126 or more on the moneyline.
• Contests with the Cubs have gone over the total set by sportsbooks in 59 of 128 chances this season.
• The Cubs are 60-68-0 against the spread in their 128 games with a line set by sportsbooks this season.
• The Giants have put together a 24-28 record in games they were listed as the moneyline underdog (winning 46.2% of those games).
• San Francisco has a record of 17-20 when it has played as a moneyline underdog with odds of +108 or longer (45.9%).
• The Giants have had an over/under set by bookmakers 131 times, and have combined with opponents to go over the total in 60 of those games (60-65-6).
• The Giants have a 57-74-0 record ATS this season.

Cubs Player Leaders

• Kyle Tucker has 122 hits this season and a team-best OBP of .374. He has a .262 batting average and a slugging percentage of .462.
• Among all qualifying hitters in the majors, his batting average ranks 68th, his on-base percentage ranks 10th, and he is 52nd in slugging.
• Tucker hopes to build on a four-game hitting streak in this matchup. During his last five outings he is batting .300 with a double, three home runs, three walks and seven RBIs.
• Pete Crow-Armstrong has 127 hits, which is best among Chicago batters this season. He's batting .256 with 66 extra-base hits. He's also slugging .510 with an on-base percentage of .295.
• Among all qualifying players, he ranks 87th in batting average, 142nd in on-base percentage and 15th in slugging percentage.
• Nico Hoerner leads Chicago in slugging percentage (.370) powered by 28 extra-base hits.
• Seiya Suzuki has been key for Chicago with 119 hits, an OBP of .319 plus a slugging percentage of .477.
• Suzuki has safely hit in three straight games. In his last five games he is hitting .167 with four walks and an RBI.

Giants Player Leaders

• Rafael Devers has put up an on-base percentage of .372 and has 124 hits, both team-best figures for the Giants. He's batting .252 and slugging .460.
• Including all the qualifying hitters in MLB, his batting average ranks 93rd, his on-base percentage is 13th, and he is 53rd in slugging.
• Jung Hoo Lee is hitting .259 with 29 doubles, 10 triples, seven home runs and 41 walks. He's slugging .408 with an on-base percentage of .322.
• Including all qualified players, he ranks 77th in batting average, 92nd in on-base percentage and 98th in slugging percentage.
• Willy Adames is batting .223 with 18 doubles, two triples, 22 home runs and 63 walks.
• Heliot Ramos leads his team with a .404 slugging percentage.

Cubs vs Giants Head to Head

• 8/26/2025: 5-2 SF (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 5/7/2025: 3-1 SF (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 5/6/2025: 14-5 SF (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/5/2025: 9-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/27/2024: 5-3 CHC (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/26/2024: 4-3 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/25/2024: 5-1 SF (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 6/24/2024: 5-4 SF (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/19/2024: 6-5 CHC (Favorite: Cubs, Spread: -1.5, Total: 11, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/18/2024: 5-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)

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