Cubs vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for July 6

Odds updated as of 9:12 a.m.

The Chicago Cubs will face the St. Louis Cardinals in MLB action on Sunday.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Cardinals Game Info

• Chicago Cubs (53-36) vs. St. Louis Cardinals (48-42)
• Date: Sunday, July 6, 2025
• Time: 6:10 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: ESPN

Cubs vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-200) | STL: (+168)
• Spread: CHC: -1.5 (+102) | STL: +1.5 (-122)
• Total: 7.5 -- Over: (-112) | Under: (-108)

Cubs vs Cardinals Probable Starting Pitchers

Probable Pitchers: Matthew Boyd (Cubs) - 8-3, 2.65 ERA vs Erick Fedde (Cardinals) - 3-8, 4.56 ERA

The Cubs will give the nod to Matthew Boyd (8-3, 2.65 ERA), who is eyeing win No. 9 on the season, and the Cardinals will turn to Erick Fedde (3-8, 4.56 ERA). When Boyd starts, his team is 7-10-0 against the spread this season. Boyd's team has won 75% of his starts when they are favored on the moneyline (9-3). The Cardinals have an 8-8-0 ATS record in Fedde's 16 starts that had a set spread. The Cardinals are 3-8 in Fedde's 11 starts this season that they were the underdog on the moneyline.

Cubs vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (63.1%)

Cubs vs Cardinals Moneyline

• The Cubs vs Cardinals moneyline has Chicago as a -200 favorite, while St. Louis is a +168 underdog on the road.

Cubs vs Cardinals Spread

• The Cardinals are at +1.5 on the runline against the Cubs. The Cardinals are -122 to cover the spread, and the Cubs are +102.

Cubs vs Cardinals Over/Under

• The Cubs-Cardinals contest on July 6 has been given an over/under of 7.5 runs. The over is set at -112 and the under at -108.

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Cubs vs Cardinals Betting Trends

• The Cubs have come away with 41 wins in the 58 contests they have been listed as the favorites in this season.
• Chicago has a record of 11-1 when favored by -200 or more this year.
• The Cubs and their opponents have hit the over in 47 of their 87 games with a total set by oddsmakers this season.
• The Cubs have posted a record of 43-44-0 against the spread this season.
• The Cardinals have been the moneyline underdog 50 total times this season. They've gone 26-24 in those games.
• St. Louis has played as a moneyline underdog of +168 or longer in only two games this season, which it lost both.
• The Cardinals have combined with opponents to go over the total 46 times this season for a 46-40-3 record against the over/under.
• The Cardinals have a 49-40-0 record against the spread this season.

Cubs Player Leaders

• Kyle Tucker leads Chicago OPS (.901) this season. He has a .283 batting average, an on-base percentage of .386, and a slugging percentage of .515.
• Among qualified hitters in baseball, his batting average ranks 36th, his on-base percentage ranks seventh, and he is 18th in slugging.
• Pete Crow-Armstrong is hitting .270 with 20 doubles, four triples, 23 home runs and 17 walks. He's slugging .552 with an on-base percentage of .308.
• He is 54th in batting average, 114th in on-base percentage and ninth in slugging among qualifying hitters.
• Seiya Suzuki has 89 hits this season and has a slash line of .261/.318/.551.
• Suzuki brings a five-game hitting streak into this matchup. In his last five games he is hitting .316 with two doubles, two home runs, three walks and six RBIs.
• Michael Busch leads Chicago with 81 hits, batting .293 this season with 35 extra-base hits.
• Busch takes a two-game hitting streak into this game. During his last five outings he is batting .550 with a double, four home runs, a walk and seven RBIs.

Cardinals Player Leaders

• Brendan Donovan has racked up an on-base percentage of .367 and a slugging percentage of .431. Both lead the Cardinals. He's batting .296.
• Including all qualified players in MLB, he is 13th in batting average, 25th in on-base percentage and 74th in slugging percentage.
• Donovan takes a four-game hitting streak into this matchup. During his last five outings he is hitting .278 with a double, a home run, three walks and an RBI.
• Nolan Arenado has 13 doubles, a triple, 10 home runs and 24 walks while hitting .244. He's slugging .391 with an on-base percentage of .304.
• He is currently 113th in batting average, 117th in on-base percentage and 111th in slugging percentage among all qualifying hitters.
• Alec Burleson leads the Cardinals with 78 hits.
• Lars Nootbaar is hitting .227 with 13 doubles, 11 home runs and 46 walks.

Cubs vs Cardinals Head to Head

• 7/5/2025: 8-6 STL (Favorite: Cubs, Spread: -1.5, Total: 11, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 7/4/2025: 11-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/26/2025: 3-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/25/2025: 8-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/24/2025: 8-7 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/23/2025: 8-2 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/4/2024: 6-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 8/3/2024: 5-4 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/2/2024: 6-3 CHC (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/1/2024: 5-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)

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