Clemson vs LSU Prediction, Odds, Picks, Best Bets for Week 1 2025

Saturday's slate in college football includes a matchup between the Clemson Tigers and the LSU Tigers.

We've got you covered, in terms of the vital info regarding NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Clemson vs LSU Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Clemson: (-182) | LSU: (+150)
• Spread: Clemson: -4.5 (-106) | LSU: +4.5 (-114)
• Total: 57.5 -- Over: (-104) | Under: (-118)

Clemson vs LSU Betting Trends

• Clemson was 6-8-0 against the spread last year.
• Clemson went 5-5 as at least 4.5-point favorites last year.
• In 14 Clemson games last year, six went over the total.
• LSU posted a 5-8-0 record against the spread last year.
• There were five LSU games (out of 13) that hit the over last year.

Clemson vs LSU Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Tigers win (63.7%)

Clemson vs LSU Point Spread

Clemson is a 4.5-point favorite against LSU. Clemson is -106 to cover the spread, and LSU is -114.

Clemson vs LSU Over/Under

The over/under for Clemson-LSU on Aug. 30 is 57.5. The over is -104, and the under is -118.

Clemson vs LSU Moneyline

The moneyline numbers for Clemson vs. LSU reveal Clemson as the favorite (-182) and LSU as the underdog (+150).

Clemson vs. LSU Points Insights

• The Clemson Tigers had an average implied point total of 35.0 last season, which is 4.0 points higher than their implied total in Saturday's game (31).
• The LSU Tigers' average implied point total last season (33.8 points) is 6.8 points higher than their implied total in this matchup (27 points).

Clemson vs. LSU Game Info

• Game day: Saturday, August 30, 2025
• Game time: 7:30 p.m. ET
• TV channel: ABC
• Location: Clemson, South Carolina
• Stadium: Memorial Stadium (Clemson, SC)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth Clemson vs. LSU analysis on FanDuel Research.