Clemson vs Florida State Prediction, Odds, Picks, Best Bets for Week 11 2025

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The Saturday schedule in college football includes a matchup between the Clemson Tigers and the Florida State Seminoles.

We've got you covered, in terms of the most important info regarding NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Clemson vs Florida State Odds & Spread

All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
Moneyline: Clemson: (-120) | Florida State: (+102)
Spread: Clemson: -1.5 (-110) | Florida State: +1.5 (-110)
Total: 56.5 -- Over: (-110) | Under: (-110)

Clemson has posted two wins against the spread this year.
Clemson has two wins ATS (2-6) as a 1.5-point or higher favorite in 2025.
There have been four Clemson games (of eight) that hit the over this season.
Florida State has beaten the spread three times in seven games.
Florida State has one win ATS (1-1) as a 1.5-point underdog or more this year.
Florida State has played seven games this season, and four of them have hit the over.

All college football win probability predictions and picks are according to numberFire.
Prediction: Seminoles win (65.1%)

Florida State is a 1.5-point underdog against Clemson. Florida State is -110 to cover the spread, and Clemson is -110.

The over/under for the Clemson versus Florida State matchup on Nov. 8 has been set at 56.5, with -110 odds on the over and -110 odds on the under.

Looking at the moneyline for Clemson-Florida State, Clemson is the favorite at -120, and Florida State is +102.

	Point Scored (PG)	Points Scored CFB Rank	Points Allowed (PG)	Points Allowed CFB Rank	Average Total	Total Games
Clemson	28.4	79	24.0	45	52.5	8
Florida State	40.0	16	20.6	25	54.2	8

Check out even more in-depth Clemson vs. Florida State analysis on FanDuel Research.

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