Clemson vs Duke Prediction, Odds, Picks, Best Bets for Week 10 2025

The college football schedule on Saturday includes the Clemson Tigers facing the Duke Blue Devils.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Clemson vs Duke Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Clemson: (-136) | Duke: (+116)
• Spread: Clemson: -2.5 (-112) | Duke: +2.5 (-108)
• Total: 55.5 -- Over: (-110) | Under: (-110)

Clemson vs Duke Betting Trends

• Clemson has posted two wins against the spread this season.
• Clemson has won twice ATS (2-5) as a 2.5-point or bigger favorite this season.
• This year, three of Clemson's seven games have hit the over.
• Against the spread, Duke is 3-4-0 this year.
• Duke has no wins ATS (0-1) as a 2.5-point underdog or greater this year.
• Of seven Duke games so far this season, five have hit the over.

Clemson vs Duke Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Tigers win (51.4%)

Clemson vs Duke Point Spread

Duke is an underdog by 2.5 points against Clemson. Duke is -108 to cover the spread, and Clemson is -112.

Clemson vs Duke Over/Under

An over/under of 55.5 has been set for Clemson-Duke on Nov. 1, with the over being -110 and the under -110.

Clemson vs Duke Moneyline

Looking at the moneyline for Clemson-Duke, Clemson is the favorite at -136, and Duke is +116.

Clemson vs. Duke Points Insights

Clemson vs. Duke Game Info

• Game day: Saturday, November 1, 2025
• Game time: 12 p.m. ET
• TV channel: ACC Network
• Location: Clemson, South Carolina
• Stadium: Memorial Stadium (Clemson, SC)

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Check out even more in-depth Clemson vs. Duke analysis on FanDuel Research.