Christian McCaffrey Fantasy Football Week 16: Stats and Projections vs. Colts

Running back Christian McCaffrey has a matchup against the fourth-ranked rushing defense in the NFL (95.1 yards conceded per game) in Week 16, when his San Francisco 49ers take on the Indianapolis Colts, Monday at 8:15 p.m. ET.

For more info on McCaffrey, if you're considering him for your DFS lineup, scroll down prior to his upcoming game against the Colts.

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Christian McCaffrey Week 16 Fantasy Football Projection

• Matchup: San Francisco 49ers at Indianapolis Colts
• Game Date: December 22, 2025
• Game Time: 8:15 p.m.
• Projected Fantasy Points: 17.9
• PPR Projected Fantasy Points: 20.5
• Projected Rushing Yards: 76.91
• Projected Rushing TDs: 0.61
• Projected Receiving Yards: 47.58
• Projected Receiving TDs: 0.32

Projections provided by numberFire

McCaffrey Fantasy Performance

• McCaffrey has been one of the best players in fantasy at the RB position this season, ranking fourth with 18.4 fantasy points per game (258.2 total points). He is 15th in fantasy points among all players.
• During his last three games, McCaffrey has delivered 48.3 total fantasy points (16.1 per game), running the ball 66 times for 215 yards and three scores. As a receiver, he has tacked on 88 yards on 12 receptions (12 targets).
• McCaffrey has put up 88.0 fantasy points (17.6 per game) over his last five games, running for 326 yards with five touchdowns on 91 carries. He has also contributed 194 yards on 25 catches (28 targets) with one TDs as a receiver.
• The peak of McCaffrey's fantasy season was a Week 7 performance versus the Atlanta Falcons, a game when he came through with seven catches and 72 receiving yards (32.1 fantasy points).
• From a fantasy perspective, Christian McCaffrey disappointed his fantasy managers against the Houston Texans in Week 8, when he mustered only 6.8 fantasy points (8 carries, 25 yards; 3 receptions, 43 yards). It was his worst fantasy effort of the year.

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Colts Defensive Performance

• Indianapolis has conceded more than 300 yards passing to four players this season.
• The Colts have allowed at least one passing TD to 10 opposing QBs this season.
• Indianapolis has allowed two or more passing TDs to five opposing QBs this year.
• Three players have thrown for at least three touchdowns in a game against the Colts this year.
• A total of six players have put up more than 100 yards receiving in a game against Indianapolis this season.
• A total of 18 players have caught a touchdown pass versus the Colts this season.
• No player has caught more than one touchdown pass against Indianapolis this year.
• One player has put up more than 100 yards rushing in a game against the Colts this year.
• Indianapolis has allowed at least one rushing TD to 10 players this season.
• The Colts have allowed three players to score more than one rushing TD in a game this season.

Want more data and analysis on Christian McCaffrey? Check out FanDuel Research for all the latest and in-depth fantasy and betting coverage.