Chiefs vs Titans Prediction, Odds, Picks, Best Bets for NFL Week 16

The NFL's Sunday slate includes the Kansas City Chiefs facing the Tennessee Titans.

Before you place your bet on this game at FanDuel Sportsbook, here are the NFL moneyline insights you need to know.

Chiefs vs Titans Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Chiefs win (73.6%)

Chiefs vs Titans Point Spread

The Chiefs are 3.5-point favorites against the Titans. The Chiefs are -104 to cover the spread, while the Titans are -118 to cover as a 3.5-point underdog.

Chiefs vs Titans Over/Under

A combined point total of 37.5 has been set for Chiefs-Titans on Dec. 21, with the over at -110 and the under at -110.

Chiefs vs Titans Moneyline

The moneyline numbers for Chiefs vs. Titans reveal Kansas City as the favorite (-178) and Tennessee as the underdog (+150) despite being the home team.

Chiefs vs Titans Betting Trends

• Against the spread, Kansas City is 5-9-0 this season.
• As 3.5-point favorites or more, the Chiefs are 3-6 against the spread.
• Out of 14 Chiefs games so far this season, four have hit the over.
• The Titans are 6-8-0 against the spread this season.
• Tennessee is 6-8 as 3.5-point or bigger underdogs in 2025.
• The Titans have seen nine of their 14 games hit the over.

Check out even more in-depth Chiefs vs. Titans analysis on FanDuel Research.

Chiefs vs Titans Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: KC: (-178) | TEN: (+150)
• Spread: KC: -3.5 (-104) | TEN: +3.5 (-118)
• Total: 37.5 -- Over: (-110) | Under: (-110)

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