Celtics vs. Cavaliers Prediction, Odds, Picks, Best Bets for Oct. 29

Celtics vs. Cavaliers Game Info

• Date: Wednesday, October 29, 2025
• Time: 7 p.m. ET
• Venue: TD Garden -- Boston, Massachusetts
• Coverage: ESPN, NBCS-BOS, and FDSOH

The Cleveland Cavaliers (3-1) are 4.5-point favorites as they attempt to extend a three-game winning streak when they visit the Boston Celtics (1-3) on Wednesday, October 29, 2025 at TD Garden. The matchup airs at 7 p.m. ET on ESPN, NBCS-BOS, and FDSOH. The matchup's over/under is 232.5.

Celtics vs. Cavaliers Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Celtics vs. Cavaliers Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Celtics win (54.7%)

Celtics vs. Cavaliers Betting Trends

• The Cavaliers compiled a 47-33-2 ATS record last year.
• As a 4.5-point underdog or greater, the Celtics had one win ATS (1-1) last season.
• Last season, the combined scoring went over the point total 50 times in Cavaliers games.
• Last year, 37 of the Celtics' 82 games hit the over.
• Against the spread last season, Cleveland played worse at home, covering 23 times in 41 home games, and 24 times in 41 road games.
• Against the spread last season, Boston had better results on the road (21-19-1) than at home (18-23-0).

Cavaliers Leaders

• Donovan Mitchell collected 24 points, 4.5 rebounds and 5 assists last season. He also drained 44.3% of his shots from the floor and 36.8% from 3-point range, with 3.3 triples per game (eighth in league).
• Evan Mobley put up 18.5 points, 9.3 boards and 3.2 assists. He sank 55.7% of his shots from the field and 37% from beyond the arc, with 1.2 triples per game.
• Darius Garland's numbers last season were 20.6 points, 2.9 boards and 6.7 assists per contest. He made 47.2% of his shots from the field and 40.1% from beyond the arc, with an average of 2.8 treys.
• Jarrett Allen put up 13.5 points, 9.7 rebounds and 1.9 assists. He made 70.6% of his shots from the floor (first in league).
• De'Andre Hunter's numbers last season were 17 points, 4 rebounds and 1.4 assists per game. He drained 47% of his shots from the floor and 40.5% from beyond the arc, with an average of 2.5 triples.

Celtics Leaders

• Jayson Tatum averaged 26.8 points, 8.7 rebounds and 6 assists last year, shooting 45.2% from the field and 34.3% from downtown, with 3.5 made treys per contest (fourth in league).
• Derrick White's numbers last season were 16.4 points, 4.5 rebounds and 4.8 assists per game, shooting 44.2% from the floor and 38.4% from beyond the arc, with an average of 3.5 made 3-pointers (fourth in league).
• Jaylen Brown recorded 22.2 points, 5.8 rebounds and 4.5 assists, shooting 46.3% from the field and 32.4% from beyond the arc, with 1.8 made treys per game.
• Anfernee Simons' stats last season were 19.3 points, 2.7 boards and 4.8 assists per contest, shooting 42.6% from the field and 36.3% from beyond the arc, with an average of 3.1 made treys.
• Payton Pritchard recorded 14.3 points, 3.5 assists and 3.8 boards.

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