Cardinals vs Titans Prediction, Odds, Picks, Best Bets for NFL Week 5

On Sunday in the NFL, the Arizona Cardinals are up against the Tennessee Titans.

Before you place your bet on this game at FanDuel Sportsbook, here are the NFL moneyline insights you need to know.

Cardinals vs Titans Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (86.6%)

Cardinals vs Titans Point Spread

The Cardinals are 8.5-point favorites against the Titans. The Cardinals are -104 to cover the spread, while the Titans are -118 to cover as an 8.5-point underdog.

Cardinals vs Titans Over/Under

Cardinals versus Titans, on Oct. 5, has an over/under of 41.5, with the over being -102 and the under -120.

Cardinals vs Titans Moneyline

Tennessee is a +350 underdog on the moneyline, while Arizona is a -450 favorite on the road.

Cardinals vs Titans Betting Trends

• Arizona has two wins against the spread this season.
• One of the Cardinals' four games this season has hit the over.
• The Titans have won once against the spread this year.
• Tennessee has covered every time (1-0) as an 8.5-point or greater underdog this year.
• Two of the Titans' four games in 2025 have hit the over.

Check out even more in-depth Cardinals vs. Titans analysis on FanDuel Research.

Cardinals vs Titans Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-450) | TEN: (+350)
• Spread: ARI: -8.5 (-104) | TEN: +8.5 (-118)
• Total: 41.5 -- Over: (-102) | Under: (-120)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!