Cardinals vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 27

Odds updated as of 10:12 a.m.

MLB action on Wednesday includes the St. Louis Cardinals playing the Pittsburgh Pirates.

We've got you covered, in terms of the vital info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cardinals vs Pirates Game Info

• St. Louis Cardinals (65-68) vs. Pittsburgh Pirates (58-75)
• Date: Wednesday, August 27, 2025
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Fox Sports 1, FDSMW, and SportsNet PT

Cardinals vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-174) | PIT: (+146)
• Spread: STL: -1.5 (+126) | PIT: +1.5 (-152)
• Total: 7.5 -- Over: (-105) | Under: (-115)

Cardinals vs Pirates Probable Starting Pitchers

Probable Pitchers: Sonny Gray (Cardinals) - 12-6, 4.33 ERA vs Carmen Mlodzinski (Pirates) - 3-7, 3.89 ERA

The Cardinals will give the ball to Sonny Gray (12-6, 4.33 ERA), who is eyeing win No. 13 on the season, and the Pirates will counter with Carmen Mlodzinski (3-7, 3.89 ERA). Gray's team is 13-11-0 against the spread this season in his starts. Gray's team is 12-4 this season when he starts and they are the moneyline favorite. The Pirates are 5-5-0 ATS in Mlodzinski's 10 starts with a set spread. The Pirates have been the underdog on the moneyline in 10 of Mlodzinski's starts this season, and they went 3-7 in those games.

Cardinals vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (61.8%)

Cardinals vs Pirates Moneyline

• Pittsburgh is the underdog, +146 on the moneyline, while St. Louis is a -174 favorite at home.

Cardinals vs Pirates Spread

• The Cardinals are hosting the Pirates and are favored by 1.5 runs on the spread. The Cardinals are +126 to cover the runline, with the Pirates being -152.

Cardinals vs Pirates Over/Under

• The over/under for Cardinals-Pirates on Aug. 27 is 7.5. The over is -105, and the under is -115.

Bet on St. Louis Cardinals vs. Pittsburgh Pirates on FanDuel today!

Cardinals vs Pirates Betting Trends

• The Cardinals have been chosen as favorites in 57 games this year and have walked away with the win 29 times (50.9%) in those games.
• This season St. Louis has been victorious three times in five chances when named as a favorite of at least -174 on the moneyline.
• The Cardinals and their opponents have gone over the total this season in 67 of their 127 opportunities.
• The Cardinals are 64-63-0 against the spread in their 127 games with a line set by sportsbooks this season.
• The Pirates have a 35-50 record in games they were the underdog on the moneyline (winning 41.2% of those games).
• In games it has played as a moneyline underdog with odds of +146 or longer, Pittsburgh has a 9-20 record (winning only 31% of its games).
• In the 125 games oddsmakers have set an over/under for the Pirates, they have combined with opponents to go over the total 50 times (50-69-6).
• The Pirates are 68-57-0 against the spread this season.

Cardinals Player Leaders

• Alec Burleson leads St. Louis in slugging percentage (.459) and total hits (123) this season. He's batting .291 with an on-base percentage of .341.
• Among qualifying hitters in MLB, his batting average ranks 15th, his on-base percentage ranks 56th, and he is 54th in slugging.
• Burleson will look for his fifth straight game with a hit in this matchup. During his last five outings he is hitting .364 with a double, a home run and three RBIs.
• Willson Contreras is hitting .259 with 30 doubles, 19 home runs and 40 walks, while slugging .455 with an on-base percentage of .343.
• Among qualified hitters, his batting average ranks him 77th, his on-base percentage 53rd, and his slugging percentage 59th.
• Masyn Winn is batting .256 with a .372 slugging percentage and 47 RBI this year.
• Lars Nootbaar has been key for St. Louis with 95 hits, an OBP of .326 plus a slugging percentage of .379.

Pirates Player Leaders

• Bryan Reynolds has put up a slugging percentage of .414 and has 122 hits, both team-best marks for the Pirates. He's batting .247 and with an on-base percentage of .306.
• Including all the qualifying players in the big leagues, he is 103rd in batting average, 122nd in on-base percentage and 92nd in slugging percentage.
• Oneil Cruz is batting .205 with 17 doubles, two triples, 18 home runs and 55 walks. He's slugging .394 with an on-base percentage of .303.
• His batting average ranks 156th among all qualified players, his on-base percentage is 127th, and he is 118th in slugging.
• Andrew McCutchen a has .333 on-base percentage to pace the Pirates.
• Isiah Kiner-Falefa has 19 doubles, two triples, a home run and 17 walks while batting .267.

Cardinals vs Pirates Head to Head

• 8/26/2025: 8-3 PIT (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/25/2025: 7-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/2/2025: 5-0 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/1/2025: 1-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 5/7/2025: 5-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 5/6/2025: 2-1 STL (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/5/2025: 6-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 4/9/2025: 2-1 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/8/2025: 5-3 STL (Favorite: Pirates, Spread: -1.5, Total: 6.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 4/7/2025: 8-4 PIT (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)

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