Cardinals vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 5

Odds updated as of 8:12 p.m.

Friday's slate in the MLB includes a matchup between the St. Louis Cardinals and the San Francisco Giants.

All the information you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cardinals vs Giants Game Info

• St. Louis Cardinals (70-71) vs. San Francisco Giants (71-69)
• Date: Friday, September 5, 2025
• Time: 8:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and NBCS-BA

Cardinals vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-116) | SF: (-102)
• Spread: STL: +1.5 (-192) | SF: -1.5 (+158)
• Total: 8.5 -- Over: (-104) | Under: (-118)

Cardinals vs Giants Probable Starting Pitchers

Probable Pitchers: Michael McGreevy (Cardinals) - 6-2, 4.17 ERA vs Carson Seymour (Giants) - 0-2, 4.74 ERA

This contest's pitching matchup is set, as the Cardinals will send Michael McGreevy (6-2) to the mound, while Carson Seymour (0-2) will get the nod for the Giants. McGreevy and his team are 7-4-0 ATS this season when he starts. McGreevy's team has been victorious in 60% of the games he's started as the moneyline favorite with a record of 3-2. Seymour has started only one game with a set spread, which the Giants failed to cover. The Giants were the underdog on the moneyline for one Seymour start this season -- they lost.

Cardinals vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (61%)

Cardinals vs Giants Moneyline

• San Francisco is a -102 underdog on the moneyline, while St. Louis is a -116 favorite at home.

Cardinals vs Giants Spread

• The Giants are 1.5-run favorites against the spread for this matchup with the Cardinals. The Giants are +158 to cover, while the Cardinals are -192 to cover as a 1.5-run underdog on the runline.

Cardinals vs Giants Over/Under

• The over/under for the Cardinals versus Giants contest on Sept. 5 has been set at 8.5, with -104 odds on the over and -118 odds on the under.

Bet on St. Louis Cardinals vs. San Francisco Giants on FanDuel today!

Cardinals vs Giants Betting Trends

• The Cardinals have been victorious in 31, or 50.8%, of the 61 contests they have been chosen as favorites in this season.
• This season St. Louis has come away with a win 27 times in 55 chances when named as a favorite of at least -116 on the moneyline.
• Contests with the Cardinals have gone over the total set by bookmakers in 70 of 135 chances this season.
• The Cardinals are 69-66-0 against the spread in their 135 games with a line set by sportsbooks this season.
• The Giants have gone 25-29 in games they were the underdog on the moneyline (winning 46.3% of those games).
• San Francisco has a 21-25 record (winning 45.7% of its games) when it has played as a moneyline underdog of -102 or longer.
• In the 139 games bookmakers have set an over/under for the Giants, they have combined with opponents to go over the total 66 times (66-66-7).
• The Giants have put together a 64-75-0 record ATS this season (covering 46% of the time).

Cardinals Player Leaders

• Masyn Winn is hitting .255 with 27 doubles, nine home runs and 33 walks. He has an on-base percentage of .311 and a slugging percentage of .367.
• Among qualifying hitters in MLB, his batting average ranks 89th, his on-base percentage ranks 115th, and he is 139th in slugging.
• Lars Nootbaar is hitting .243 with 22 doubles, a triple, 13 home runs and 55 walks, while slugging .387 with an on-base percentage of .332.
• He is 115th in batting average, 73rd in on-base percentage and 125th in slugging in the major leagues.
• Ivan Herrera has 88 hits this season and has a slash line of .284/.367/.445.
• Victor Scott II has five home runs, 35 RBI and a batting average of .223 this season.

Giants Player Leaders

• Rafael Devers has put up a team-high OBP (.380), while leading the Giants in hits (138). He's batting .262 and slugging.
• Including all the qualified players in the majors, he ranks 67th in batting average, 10th in on-base percentage and 27th in slugging percentage.
• Devers takes a four-game hitting streak into this game. During his last five outings he is batting .318 with a double, three home runs, two walks and six RBIs.
• Jung Hoo Lee is batting .262 with 30 doubles, 10 triples, seven home runs and 44 walks. He's slugging .406 with an on-base percentage of .326.
• Including all qualified hitters, he ranks 67th in batting average, 86th in on-base percentage and 100th in slugging percentage.
• Willy Adames is batting .230 with 18 doubles, two triples, 26 home runs and 66 walks.
• Heliot Ramos' .405 slugging percentage leads his team.

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