Canucks vs Penguins NHL Prediction, Odds, Picks, Best Bets for Oct. 21

The Tuesday slate in the NHL includes a matchup between the Vancouver Canucks and the Pittsburgh Penguins.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NHL moneyline insights you need to know.

Canucks vs Penguins Game Info

• Vancouver Canucks (4-2) vs. Pittsburgh Penguins (4-2)
• Date: Tuesday, October 21, 2025
• Time: 7 p.m. ET
• Venue: PPG Paints Arena -- Pittsburgh, Pennsylvania
• Coverage: ESPN+

Canucks vs Penguins Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Canucks vs Penguins Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

• Prediction: Canucks win (53.6%)

Canucks vs Penguins Puck Line

• The Penguins are underdogs by 1.5 goals at home against the Canucks. The Penguins are -260 to cover the spread, and the Canucks are +205.

Canucks vs Penguins Over/Under

• Canucks versus Penguins, on Oct. 21, has an over/under of 6.5, with the over being +104 and the under -128.

Canucks vs Penguins Moneyline

• Looking at the moneyline for Canucks-Penguins, Vancouver is the favorite at -113, and Pittsburgh is -105 playing at home.

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