Bucks vs. Pistons Prediction, Odds, Picks, Best Bets for Nov. 22

Bucks vs. Pistons Game Info

• Date: Saturday, November 22, 2025
• Time: 8 p.m. ET
• Venue: Fiserv Forum -- Milwaukee, Wisconsin
• Coverage: FDSDET, FDSWI, and NBA TV

The Detroit Pistons (13-2) are 8-point favorites as they try to build on an 11-game winning streak when they visit the Milwaukee Bucks (8-8) on Saturday, November 22, 2025 at Fiserv Forum. The matchup airs at 8 p.m. ET on FDSDET, FDSWI, and NBA TV. The matchup has an over/under of 223.5 points.

Bucks vs. Pistons Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Bucks vs. Pistons Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Bucks win (59.8%)

Bucks vs. Pistons Betting Trends

• The Pistons have covered the spread in a matchup 11 times this season (11-4-0).
• The Bucks are 7-9-0 against the spread this year.
• This season, Pistons games have hit the over eight times out of 16 chances.
• Bucks games this year have gone over the point total 50% of the time (eight out of 16 games with a set point total).
• Against the spread, Detroit has performed better when playing at home, covering seven times in nine home games, and four times in six road games.
• The Pistons have exceeded the total more often at home, hitting the over in six of nine home matchups (66.7%). On the road, they have hit the over in two of six games (33.3%).
• Milwaukee has performed better against the spread at home (5-4-0) than on the road (2-5-0) this year.
• Looking at the over/under, Bucks games have gone over six of nine times at home (66.7%), and two of seven on the road (28.6%).

Pistons Leaders

• Cade Cunningham is averaging 27.3 points, 5.4 boards and 9.9 assists. Defensively, he averages 1.4 steals and 0.8 blocked shots.
• Jalen Duren is averaging 20.6 points, 1.8 assists and 11.9 boards.
• Ausar Thompson averages 13.2 points, 6.2 rebounds and 3.1 assists, shooting 50.8% from the field.
• Duncan Robinson's numbers on the season are 12.7 points, 2.8 rebounds and 2 assists per game, shooting 44.7% from the floor and 41.8% from downtown, with an average of 3.1 made 3-pointers.
• Isaiah Stewart is averaging 11.1 points, 6.5 boards and 1.5 assists. Defensively, he averages 0.2 steals and 2 blocked shots (fourth in league).

Bucks Leaders

• Ryan Rollins averages 18.3 points for the Bucks, plus 3.9 boards and 5.9 assists.
• Myles Turner averages 12.4 points, 6.5 rebounds and 1.8 assists. He is also draining 43.6% of his shots from the field and 42.4% from beyond the arc, with 2.4 treys per game.
• The Bucks are getting 13.5 points, 4.3 boards and 1.9 assists per game from Kyle Kuzma.
• Cole Anthony averages 8.5 points, 3.3 rebounds and 5.3 assists. He is draining 41.2% of his shots from the floor.
• The Bucks are getting 10.3 points, 5.7 rebounds and 1.1 assists per game from Bobby Portis.

For more NBA betting insights, check out FanDuel Research's NBA home page.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Watch FanDuel TV's NBA show "Run It Back" with Lou Williams, Michelle Beadle, DeMarcus "Boogie" Cousins and Chandler Parsons weekdays at 10am ET on FanDuel TV, the Run It Back YouTube page, or download the podcast here: fanduel.com/research/tv-and-podcast.