Brewers vs Cubs Prediction, Odds, Moneyline, Spread & Over/Under for NLDS Game 2 on Oct. 6

Odds updated as of 8:12 p.m.

The Milwaukee Brewers versus the Chicago Cubs in Game 2 of the NLDS is on the MLB schedule for Monday.

We've got you covered, in terms of the most important information regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Brewers vs Cubs Game Info

• Milwaukee Brewers (97-65) vs. Chicago Cubs (92-70)
• Date: Monday, October 6, 2025
• Time: 9:08 p.m. ET
• Venue: American Family Field -- Milwaukee, Wisconsin
• Coverage: TBS, truTV, and HBO Max

Brewers vs Cubs Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-136) | CHC: (+116)
• Spread: MIL: -1.5 (+152) | CHC: +1.5 (-184)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Brewers vs Cubs Probable Starting Pitchers

Probable Pitchers: Aaron Ashby (Brewers) - 5-2, 2.16 ERA vs Shota Imanaga (Cubs) - 9-8, 3.73 ERA

The Brewers will give the nod to Aaron Ashby (5-2, 2.16 ERA) versus the Cubs and Shota Imanaga (9-8, 3.73 ERA). Ashby and his team failed to cover the spread in his only opportunity this season as a starter. Ashby's team lost his only start as a favorite this season. The Cubs have a 9-15-0 record against the spread in Imanaga's starts. The Cubs have been the moneyline underdog in eight of Imanaga's starts this season, and they went 4-4 in those matchups.

Brewers vs Cubs Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (57%)

Brewers vs Cubs Moneyline

• Milwaukee is the favorite, -136 on the moneyline, while Chicago is a +116 underdog on the road.

Brewers vs Cubs Spread

• The Cubs are +1.5 on the spread (-184 to cover), and Milwaukee is +152 to cover the runline.

Brewers vs Cubs Over/Under

• A combined run total of 7.5 has been set for Brewers-Cubs on Oct. 6, with the over at -115 and the under at -105.

Bet on Milwaukee Brewers vs. Chicago Cubs on FanDuel today!

Brewers vs Cubs Betting Trends

• The Brewers have come away with 61 wins in the 97 contests they have been listed as the favorites in this season.
• This year Milwaukee has won 40 of 54 games when listed as at least -136 on the moneyline.
• The Brewers and their opponents have hit the over in 80 of their 160 games with a total set by oddsmakers this season.
• The Brewers are 88-72-0 against the spread in their 160 games with a line set by sportsbooks this season.
• The Cubs have compiled an 18-27 record in games they were the underdog on the moneyline (winning 40% of those games).
• Chicago is 5-10 (winning just 33.3% of its games) when it has played as a moneyline underdog of +116 or longer.
• In the 161 games oddsmakers have set an over/under for the Cubs, they have combined with opponents to go over the total 75 times (75-75-11).
• The Cubs have a 77-84-0 record ATS this season (covering 47.8% of the time).

Brewers Player Leaders

• Brice Turang has an OPS of .794, fueled by an OBP of .359 to go with a slugging percentage of .435. He has a .288 batting average, as well.
• Among the qualified batters in baseball, his batting average ranks 16th, his on-base percentage ranks 20th, and he is 71st in slugging.
• Turang will look for his sixth straight game with a hit in this matchup. In his last five games he is hitting .421 with three doubles, three walks and five RBIs.
• Christian Yelich has 21 doubles, 29 home runs and 64 walks. He's batting .264 and slugging .452 with an on-base percentage of .343.
• Among qualified batters, his batting average places him 51st, his on-base percentage 49th, and his slugging percentage 56th.
• William Contreras has collected 147 base hits, an OBP of .355 and a slugging percentage of .399 this season.
• Jackson Chourio leads Milwaukee in total hits (148) this season while batting .270 with 60 extra-base hits.
• Chourio brings a three-game hitting streak into this matchup. During his last five outings he is batting .368 with two doubles, a home run, two walks and four RBIs.

Cubs Player Leaders

• Kyle Tucker has accumulated an on-base percentage of .377, a team-high for the Cubs. He's batting .266 and slugging .464.
• Including all the qualified hitters in MLB, he ranks 46th in batting average, seventh in on-base percentage and 44th in slugging percentage.
• Nico Hoerner leads his team with a .394 slugging percentage. He has a batting average of .297 with an on-base percentage of .345.
• His batting average is eighth among all qualified players, his on-base percentage ranks 46th, and he is 110th in slugging.
• Pete Crow-Armstrong is batting .247 with 37 doubles, four triples, 31 home runs and 29 walks.
• Seiya Suzuki has 31 doubles, three triples, 32 home runs and 71 walks while batting .245.

Brewers vs Cubs Head to Head

• 10/4/2025: 9-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 8/21/2025: 4-1 MIL (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 8/20/2025: 4-3 CHC (Favorite: Brewers, Spread: -1.5, Total: 6.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/19/2025: 4-1 CHC (Favorite: Brewers, Spread: -1.5, Total: 6.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/19/2025: 6-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/18/2025: 7-0 MIL (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/30/2025: 10-3 CHC (Favorite: Brewers, Spread: -1.5, Total: 7, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/29/2025: 9-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/28/2025: 8-4 MIL (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/19/2025: 8-7 MIL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)

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