Bills vs Patriots Prediction, Odds, Picks, Best Bets for NFL Week 5 Sunday Night Football

The Buffalo Bills will face the New England Patriots in NFL action on Sunday.

All the info you need is below, in order to make a smart bet on this game at FanDuel Sportsbook.

Bills vs Patriots Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Bills win (77.5%)

Bills vs Patriots Point Spread

The Bills are 8.5-point favorites against the Patriots. The Bills are -108 to cover the spread, while the Patriots are -112 to cover as an 8.5-point underdog.

Bills vs Patriots Over/Under

The Bills-Patriots matchup on Oct. 5 has been given an over/under of 49.5 points. The over is -110 and the under is -110.

Bills vs Patriots Moneyline

New England is the underdog, +320 on the moneyline, while Buffalo is a -405 favorite at home.

Bills vs Patriots Betting Trends

• Buffalo has posted two wins against the spread this season.
• The Bills have no wins ATS (0-2) as an 8.5-point favorite or greater this season.
• The Bills have seen three of their four games hit the over.
• The Patriots have posted two wins against the spread this year.
• Two of the Patriots' four games in 2025 have hit the over.

Check out even more in-depth Bills vs. Patriots analysis on FanDuel Research.

Bills vs Patriots Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BUF: (-405) | NE: (+320)
• Spread: BUF: -8.5 (-108) | NE: +8.5 (-112)
• Total: 49.5 -- Over: (-110) | Under: (-110)

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