Bills vs Browns Prediction, Odds, Picks, Best Bets for NFL Week 16

The NFL slate on Sunday includes the Buffalo Bills taking on the Cleveland Browns.

Get the latest NFL odds ahead of this matchup on FanDuel Sportsbook.

Bills vs Browns Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Bills win (69.1%)

Bills vs Browns Point Spread

The Bills are 10.5-point favorites against the Browns. The Bills are +100 to cover the spread, while the Browns are -122 to cover as a 10.5-point underdog.

Bills vs Browns Over/Under

Bills versus Browns on Dec. 21 has an over/under of 41.5 points, with the over -120 and the under -102.

Bills vs Browns Moneyline

The moneyline numbers for Bills vs. Browns reveal Buffalo as the favorite (-649) and Cleveland as the underdog (+480) despite being the home team.

Bills vs Browns Betting Trends

• Buffalo's record against the spread is 7-7-0.
• The Bills are winless ATS (0-2) when playing as at least 10.5-point favorites this year.
• The Bills have seen seven of their 14 games hit the over.
• The Browns have covered the spread five times in 14 games.
• Cleveland has no wins ATS (0-1) as a 10.5-point underdog or greater this season.
• The Browns have played 14 games this year, and seven of them have gone over the total.

Check out even more in-depth Bills vs. Browns analysis on FanDuel Research.

Bills vs Browns Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BUF: (-649) | CLE: (+480)
• Spread: BUF: -10.5 (100) | CLE: +10.5 (-122)
• Total: 41.5 -- Over: (-120) | Under: (-102)

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