Best College Football Games Week 4: Predictions, Odds, Picks, Best Bets

The No. 6 Tennessee Volunteers and the No. 15 Oklahoma Sooners square off for one of 18 games on the college football slate in Week 4 that feature a ranked team.

To pick up an edge prior to Week 4 in college football, read our betting preview below.

Nebraska vs. Illinois

• Matchup: No. 24 Illinois Fighting Illini at No. 22 Nebraska Cornhuskers
• Projected Favorite: Nebraska (61.71% win probability)
• Spread: Nebraska (-7.5)
• Total: 43.5
• Time: 8:00 PM ET
• Date: Sept. 20
• TV Channel: FOX

Bet on Nebraska vs. Illinois with FanDuel Sportsbook.

Clemson vs. North Carolina State

• Matchup: North Carolina State Wolfpack at No. 21 Clemson Tigers
• Projected Favorite: Clemson (78.08% win probability)
• Spread: Clemson (-20.5)
• Total: 45.5
• Time: 12:00 PM ET
• Date: Sept. 21
• TV Channel: ABC

Bet on Clemson vs. North Carolina State with FanDuel Sportsbook.

Ohio State vs. Marshall

• Matchup: Marshall Thundering Herd at No. 3 Ohio State Buckeyes
• Projected Favorite: Ohio State (97.49% win probability)
• Spread: Ohio State (-39.5)
• Total: 52.5
• Time: 12:00 PM ET
• Date: Sept. 21
• TV Channel: FOX

Bet on Ohio State vs. Marshall with FanDuel Sportsbook.

Iowa State vs. Arkansas State

• Matchup: Arkansas State Red Wolves at No. 20 Iowa State Cyclones
• Projected Favorite: Iowa State (92.51% win probability)
• Spread: Iowa State (-21.5)
• Total: 51.5
• Time: 2:00 PM ET
• Date: Sept. 21
• TV Channel: ESPN+

Bet on Iowa State vs. Arkansas State with FanDuel Sportsbook.

Michigan vs. USC

• Matchup: No. 11 USC Trojans at No. 18 Michigan Wolverines
• Projected Favorite: USC (51.74% win probability)
• Spread: USC (-5.5)
• Total: 44.5
• Time: 3:30 PM ET
• Date: Sept. 21
• TV Channel: CBS

Bet on Michigan vs. USC with FanDuel Sportsbook.

Louisville vs. Georgia Tech

• Matchup: Georgia Tech Yellow Jackets at No. 19 Louisville Cardinals
• Projected Favorite: Louisville (84.43% win probability)
• Spread: Louisville (-10.5)
• Total: 57.5
• Time: 3:30 PM ET
• Date: Sept. 21
• TV Channel: ESPN2

Bet on Louisville vs. Georgia Tech with FanDuel Sportsbook.

Notre Dame vs. Miami (OH)

• Matchup: Miami (OH) RedHawks at No. 17 Notre Dame Fighting Irish
• Projected Favorite: Notre Dame (95.29% win probability)
• Spread: Notre Dame (-27.5)
• Total: 44.5
• Time: 3:30 PM ET
• Date: Sept. 21
• TV Channel: NBC

Bet on Notre Dame vs. Miami (OH) with FanDuel Sportsbook.

Penn State vs. Kent State

• Matchup: Kent State Golden Flashes at No. 10 Penn State Nittany Lions
• Projected Favorite: Penn State (98.23% win probability)
• Spread: Penn State (-48.5)
• Total: 56.5
• Time: 3:30 PM ET
• Date: Sept. 21
• TV Channel: BTN

Bet on Penn State vs. Kent State with FanDuel Sportsbook.

Northern Illinois vs. Buffalo

• Matchup: Buffalo Bulls at No. 23 Northern Illinois Huskies
• Projected Favorite: Northern Illinois (80.16% win probability)
• Spread: Northern Illinois (-14.5)
• Total: 43.5
• Time: 3:30 PM ET
• Date: Sept. 21
• TV Channel: ESPN+

Bet on Northern Illinois vs. Buffalo with FanDuel Sportsbook.

LSU vs. UCLA

• Matchup: UCLA Bruins at No. 16 LSU Tigers
• Projected Favorite: LSU (78.96% win probability)
• Spread: LSU (-24.5)
• Total: 56.5
• Time: 3:30 PM ET
• Date: Sept. 21
• TV Channel: ABC

Bet on LSU vs. UCLA with FanDuel Sportsbook.

Oklahoma State vs. Utah

• Matchup: No. 12 Utah Utes at No. 14 Oklahoma State Cowboys
• Projected Favorite: Utah (60.17% win probability)
• Spread: Oklahoma State (-2.5)
• Total: 52.5
• Time: 4:00 PM ET
• Date: Sept. 21
• TV Channel: FOX

Bet on Oklahoma State vs. Utah with FanDuel Sportsbook.

Missouri vs. Vanderbilt

• Matchup: Vanderbilt Commodores at No. 7 Missouri Tigers
• Projected Favorite: Missouri (97.05% win probability)
• Spread: Missouri (-20.5)
• Total: 52.5
• Time: 4:15 PM ET
• Date: Sept. 21
• TV Channel: SEC Network

Bet on Missouri vs. Vanderbilt with FanDuel Sportsbook.

South Florida vs. Miami (FL)

• Matchup: No. 8 Miami (FL) Hurricanes at South Florida Bulls
• Projected Favorite: Miami (FL) (86.80% win probability)
• Spread: Miami (FL) (-16.5)
• Total: 64.5
• Time: 7:00 PM ET
• Date: Sept. 21
• TV Channel: ESPN

Bet on South Florida vs. Miami (FL) with FanDuel Sportsbook.

Oklahoma vs. Tennessee

• Matchup: No. 6 Tennessee Volunteers at No. 15 Oklahoma Sooners
• Projected Favorite: Tennessee (55.55% win probability)
• Spread: Tennessee (-7.5)
• Total: 56.5
• Time: 7:30 PM ET
• Date: Sept. 21
• TV Channel: ABC

Bet on Oklahoma vs. Tennessee with FanDuel Sportsbook.

Texas A&M vs. Bowling Green

• Matchup: Bowling Green Falcons at No. 25 Texas A&M Aggies
• Projected Favorite: Texas A&M (91.58% win probability)
• Spread: Texas A&M (-22.5)
• Total: 52.5
• Time: 7:30 PM ET
• Date: Sept. 21
• TV Channel: SEC Network+

Bet on Texas A&M vs. Bowling Green with FanDuel Sportsbook.

Ole Miss vs. Georgia Southern

• Matchup: Georgia Southern Eagles at No. 5 Ole Miss Rebels
• Projected Favorite: Ole Miss (98.19% win probability)
• Spread: Ole Miss (-34.5)
• Total: 67.5
• Time: 7:45 PM ET
• Date: Sept. 21
• TV Channel: SEC Network

Bet on Ole Miss vs. Georgia Southern with FanDuel Sportsbook.

Texas vs. Louisiana-Monroe

• Matchup: Louisiana-Monroe Warhawks at No. 1 Texas Longhorns
• Projected Favorite: Texas (96.94% win probability)
• Spread: Texas (-44.5)
• Total: 53.5
• Time: 8:00 PM ET
• Date: Sept. 21
• TV Channel: SEC Network+

Bet on Texas vs. Louisiana-Monroe with FanDuel Sportsbook.

BYU vs. Kansas State

• Matchup: No. 13 Kansas State Wildcats at BYU Cougars
• Projected Favorite: Kansas State (80.50% win probability)
• Spread: Kansas State (-6.5)
• Total: 47.5
• Time: 10:30 PM ET
• Date: Sept. 21
• TV Channel: ESPN

Bet on BYU vs. Kansas State with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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