Baker Mayfield Fantasy Football Week 6: Stats and Projections vs. 49ers

Quarterback Baker Mayfield has a matchup versus the 14th-ranked pass defense in the NFL (207.6 yards conceded per game) in Week 6, when his Tampa Bay Buccaneers play the San Francisco 49ers, Sunday at 4:25 p.m. ET.

With Mayfield's next game against the 49ers, should you think about him for your daily fantasy lineup? See below for more stats and info.

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Baker Mayfield Week 6 Fantasy Football Projection

• Matchup: Tampa Bay Buccaneers vs. San Francisco 49ers
• Game Date: October 12, 2025
• Game Time: 4:25 p.m.
• Projected Fantasy Points: 19.1
• Projected Passing Yards: 256.32
• Projected Passing TDs: 2.05
• Projected Rushing Yards: 17.77
• Projected Rushing TDs: 0.15

Projections provided by numberFire

Mayfield Fantasy Performance

• Mayfield has been coming through for fantasy managers this season, as his 105.8 fantasy points (21.2 per game) rank him third at the QB position and third overall.
• Over his last three games, Mayfield has generated 63.3 fantasy points (21.1 per game), as he's amassed 901 yards on 70-of-102 passing with five touchdowns and one pick. As a runner, he's tacked on 72 rushing yards on 11 carries.
• The highlight of Mayfield's season as a fantasy producer came against the Seattle Seahawks last week, as he tallied 26.7 fantasy points by running for 15 yards on five attempts.
• From a fantasy perspective, Baker Mayfield stumbled to his worst performance of the season in Week 3 against the New York Jets, throwing for 233 yards and one touchdown with zero interceptions with 44 yards on four attempts on the ground (17.7 fantasy points).

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49ers Defensive Performance

• San Francisco has given up more than 300 yards passing to just one player this season.
• The 49ers have given up at least one passing TD to four opposing QBs this year.
• San Francisco has allowed two players to throw for at least two TDs in a game this season.
• The 49ers have allowed two players to throw for at least three TDs in a game this year.
• San Francisco has allowed just one player to put up over 100 yards receiving in a game this year.
• A total of Seven players have caught a TD pass against the 49ers this year.
• San Francisco has allowed two or more receiving touchdowns to just one player this year.
• The 49ers have given up more than 100 yards rushing to only one player this season.
• San Francisco has given up at least one rushing TD to two players this year.
• The 49ers have not allowed an opposing player to score two or more rushing TDs against them this season.

Want more data and analysis on Baker Mayfield? Check out FanDuel Research for all the latest and in-depth fantasy and betting coverage.