Alabama vs LSU Prediction, Odds, Picks, Best Bets for Week 11 2025

Saturday's slate in college football includes a matchup between the Alabama Crimson Tide and the LSU Tigers.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Alabama vs LSU Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Alabama: (-420) | LSU: (+320)
• Spread: Alabama: -10.5 (-110) | LSU: +10.5 (-110)
• Total: 49.5 -- Over: (-110) | Under: (-110)

Alabama vs LSU Betting Trends

• Alabama is 5-3-0 against the spread this year.
• Alabama's ATS record as 10.5-point or bigger favorites is 3-2.
• Out of eight Alabama games so far this season, four have gone over the total.
• LSU has covered the spread three times in eight games.
• Of eight LSU games so far this season, three have hit the over.

Alabama vs LSU Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Crimson Tide win (81.2%)

Alabama vs LSU Point Spread

Alabama is a 10.5-point favorite against LSU. Alabama is -110 to cover the spread, and LSU is -110.

Alabama vs LSU Over/Under

An over/under of 49.5 has been set for Alabama-LSU on Nov. 8, with the over being -110 and the under -110.

Alabama vs LSU Moneyline

The moneyline numbers for Alabama vs. LSU reveal Alabama as the favorite (-420) and LSU as the underdog (+320).

Alabama vs. LSU Points Insights

Alabama vs. LSU Game Info

• Game day: Saturday, November 8, 2025
• Game time: 7:30 p.m. ET
• TV channel: ABC
• Location: Tuscaloosa, Alabama
• Stadium: Bryant-Denny Stadium

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Check out even more in-depth Alabama vs. LSU analysis on FanDuel Research.