49ers vs Giants Prediction, Odds, Picks, Best Bets for NFL Week 9

On Sunday in the NFL, the San Francisco 49ers are up against the New York Giants.

All the information you need is below, in order to make a smart bet on this game at FanDuel Sportsbook.

49ers vs Giants Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: 49ers win (62.2%)

49ers vs Giants Point Spread

The 49ers are 2.5-point favorites against the Giants. The 49ers are -120 to cover the spread, while the Giants are -102 to cover as a 2.5-point underdog.

49ers vs Giants Over/Under

An over/under of 48.5 has been set for 49ers-Giants on Nov. 2, with the over being -115 and the under -105.

49ers vs Giants Moneyline

New York is a +130 underdog on the moneyline, while San Francisco is a -154 favorite at home.

49ers vs Giants Betting Trends

• San Francisco is 4-4-0 against the spread this year.
• The 49ers have one win ATS (1-1) as a 2.5-point favorite or greater this year.
• This season, four of the 49ers' eight games have gone over the point total.
• The Giants are 4-4-0 against the spread this year.
• New York is 4-3 as 2.5-point or bigger underdogs in 2025.
• This season, four of the Giants' eight games have gone over the point total.

Check out even more in-depth 49ers vs. Giants analysis on FanDuel Research.

49ers vs Giants Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-154) | NYG: (+130)
• Spread: SF: -2.5 (-120) | NYG: +2.5 (-102)
• Total: 48.5 -- Over: (-115) | Under: (-105)

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