49ers vs Colts Prediction, Odds, Picks, Best Bets for NFL Week 16 Monday Night Football

On Monday in the NFL, the San Francisco 49ers are playing the Indianapolis Colts.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital info about today's NFL betting odds.

49ers vs Colts Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: 49ers win (59.8%)

49ers vs Colts Point Spread

The 49ers are 6.5-point favorites against the Colts. The 49ers are -104 to cover the spread, while the Colts are -118 to cover as a 6.5-point underdog.

49ers vs Colts Over/Under

The over/under for 49ers-Colts on Dec. 22 is 46.5. The over is -115, and the under is -105.

49ers vs Colts Moneyline

Looking at the moneyline for Colts-49ers, Indianapolis is the underdog at +240, and San Francisco is -295 playing on the road.

49ers vs Colts Betting Trends

• San Francisco is 9-5-0 against the spread this year.
• The 49ers are unbeaten ATS (2-0) as a 6.5-point favorite or greater this year.
• The 49ers have seen eight of their 14 games go over the point total.
• Against the spread, the Colts are 8-6-0 this year.
• Indianapolis has yet to lose ATS (1-0) as a 6.5-point underdog or more this year.
• The Colts have seen seven of their 14 games hit the over.

Check out even more in-depth 49ers vs. Colts analysis on FanDuel Research.

49ers vs Colts Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-295) | IND: (+240)
• Spread: SF: -6.5 (-104) | IND: +6.5 (-118)
• Total: 46.5 -- Over: (-115) | Under: (-105)

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